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September 13, 2005
Weird: Kids' DNA Tested, Parent Informed The DNA Is Not A MatchObviously, this be a shock to the parent (but to no one else) if the parent were the father. It happens. Not exactly a medical mystery what may have happened. But in this case, the parent was the mother. Who had become pregnant, carried all her children to to term, and then gave birth to them naturally. No implanted embryos or in vitro fertilizatin or other such medical intervention was involved. Karen Keegan developed kidney problems and needed a transplant. Naturally, they checked her children for a genetic match. They found something that shocked her: her children's DNA did not match hers. She was not not their natural mother. It turns out the woman was a "chimera;" she had two separate DNA profiles. One in her blood, another in her reproductive system. Chimerism occurs in the embryo as one is devoloping -- two fraternal twins embryos grow, but then one absorbs the other, incorporating the other's DNA into different tissues and organs of its body. Most of her body had one set of DNA, but she had a Trojan set of DNA inside of her. And it was actually her embryonic twin sister which contributed her DNA to her children. I first heard of this rare (?) condition on a real stumper of a CSI in which the obvious culprit of a rape did not match the DNA he left in his victim. Turns out he was a chimera; the DNA the lab tested from his blood and saliva was simply different from the DNA in his semen. When Grissom finally got wise and figured out he might have a chimera on his hands, he got a court order for a semen sample, and then he finally got that long-anticipated genetic match. A couple of months ago a bicyclist accused of "blood doping" (filling one's veins with other's blood to gain a competitive advantage) claimed that the reason he had two different blood types in his body was that he was chimera; the other blood type in his veins was due to his absorbing his twin in utero. He wasn't believed, but it is possible. And chimerism may not be that rare-- some believe that there are many pregnancies that begin as twins, and most of these result in one embryo absorbing the other. If the twins are fraternal, chimerism may result. If the twins are of different sexes-- hermaphroditism may result. And the fact that chimerism is so infrequently checked for means that there might be a lot of false-negative paternity tests, and false-netative DNA criminological tests, too. Lydia Fairchild's children were ordered taken from her by a judge because tests consistently showed her children were not a genetic match to her. She was pregnant with a third child, and when that child was born (under court supervision), it showed that that child too was also not a match. State prosecutors stumbled across the term "chimerism" in a medical journal and tipped her lawyer. Ultimately it was proven she was a chimera -- and that her kids were in fact her own. I mention this because Discovery Health is currently running a documentary about chimerism, called "I Am My Own Twin," about the same woman profiled in that (yes, Dave) old NPR report. It also tells the story of the woman whose children were almost taken from her. The medical report the prosecutors stumbled across was about none other than Karen Keegan. Did Karen Keegan ever get her kidney transplant? Yes she did. Her children were not close enough to her genetically to donate a kidney, but, oddly enough, her non-blood-kin husband was. Funny old world. Chimeras and The Innocence Project: I'm a supporter of Barry Schect's Innocence Project -- using DNA testing to prove convicted criminals are actually innocent -- but I hope the possibility of chimerism is being examined in cases where there's a lot of non-DNA evidence that an accused is guilty of the crime charged. The thing is it's very hard to prove chimerism. Lydia Fairchild's chimerism was only demonstrated to the court by showing that while her children didn't match her DNA, they did match a mix of her father's and mother's DNA. The kids had the family's DNA-- just not her version of it. So it's not as if there's a simple test for this. The secondary DNA just lurks in different parts of the body, and isn't easy to find, even if you're specifically looking for it. posted by Ace at 12:49 AM
CommentsWow, you are just Bill Motherfuckin' Nye this week, aren't you pal? But seriously, that's fascinating. Bizzare as all hell, but fascinating. Cheers, Posted by: Dave at Garfield Ridge on September 13, 2005 01:16 AM
I've always marveled at how the efficacy of drug treatments can vary so much from person to person (though the medical establishment often seems to think one size fits all). I wonder if this means that the efficacy of a drug treatment can vary within your body? Posted by: geoff on September 13, 2005 01:20 AM
I had no idea that was Bill Nye's middle name. ;-) Posted by: Rightwingsparkle on September 13, 2005 01:47 AM
So, uh, does this mean that OJ really wasn't guilty? Posted by: Sean M. on September 13, 2005 02:58 AM
If the DNA is split, you must acquit. Posted by: geoff on September 13, 2005 03:01 AM
"I'm a supporter of Barry Schect's Innocence Project" I never thought I'd hear those words coming out of your mouth, Ace. If that's true then you should be ashamed. That horrible farce and all its equally disgusting offshoots are one of the worst abominations inflicted on law enforcement, the courts, and the people of the United States in a very long time. Posted by: Megan on September 13, 2005 03:16 AM
And not that it matters much but it's Scheck, not "Schect." He's still a worthless piece of shit. Posted by: Megan on September 13, 2005 03:18 AM
Lydia Fairchild's children were ordered taken from her by a judge because tests consistently showed her children were not a genetic match to her. Blerp? I hope there's a lot more to the story than that. Posted by: Pixy Misa on September 13, 2005 04:31 AM
On the other hand, I'm too lazy to follow the link. Posted by: Pixy Misa on September 13, 2005 04:32 AM
That's just wild. Posted by: Silk on September 13, 2005 05:54 AM
"but i hope the possibility of chimerism is being examined in cases where there's a lot of non-DNA evidence..." You mean like fingerprints on the gun or the exculpatory statement made by the criminal might really have been made by his chimeristic twin! Posted by: Steve on September 13, 2005 06:13 AM
I would have thought that the woman's immune system would have tried to destroy the organs with the "alien" genes. However, it's somehow been conditioned to accept tissue from the absorbed twin as friend rather than foe. I wonder if a similar process could be used to have the body accept an organ transplant? Posted by: Brown Line on September 13, 2005 07:38 AM
How exactly is a court order for a semen sample from an unwilling suspect carried out? Posted by: DB on September 13, 2005 08:06 AM
They get "Hand JobHerbey" to... well... give him a hand!!!1! Posted by: Madfish Willie on September 13, 2005 08:20 AM
I believe chimerism was the defense of that bicyclist (not Lance Armstrong) who got busted for blood doping; i.e., it was his explanation for how there was more than one type of blood in his system. Apparently, his claim is that the 2nd blood type was from a long lost phantom twin who never made it to birth around the time he was born. (My recollection of the story is dim, but you could look it up.) Some experts are buying the bicyclist's defense, others not. Posted by: Chimera Rouge on September 13, 2005 08:27 AM
Oh, cripes. I read your whole post, except for the part, highlighted in red, talking about the blood-doping bicyclist. What a dope I am. Sorry about that. Posted by: Chimera Rouge on September 13, 2005 08:30 AM
Wicked. So she's actually her children's aunt. Posted by: lauraw on September 13, 2005 09:24 AM
I am my own grampa. Posted by: Dave in Texas on September 13, 2005 09:43 AM
When Grissom finally got wise and figured out he might have a chimera on his hands, he got a court order for a semen sample, and then he finally got that long-anticipated genetic match. Wait a second... The court can actually order you to jack off? What if it's against your religion? That would be inhuman. Or what if you have "performance anxiety" or "equipment failure?" Can they order a cute nurse to "assist" you? Posted by: on September 13, 2005 09:44 AM
I once had a twin Posted by: I'm really sorry on September 13, 2005 09:45 AM
I once worked with a guy who was an obvious chimera, part black and part white. No joke. He had patches of low-melanin skin and red hair. > I wonder if a similar process could be used to have the body accept an organ transplant? The immune system learns to recognize "self" in early development. So a chimera would recognize both DNA lines as "self." If it turns out that replacement organs are easier to grow from certain cell lines than from others, it might be worth it to mix in a few cells from such a line when you have a baby. Then when necessary, the kid could accept a transplant from the standard, mass-produced line with no rejection problem. I was going to write an SF story about someone holding the transplant cell line hostage, but never got around to it. Posted by: Bob Hawkins on September 13, 2005 09:47 AM
Exactly how do the police get a semen sample from an uncooperative suspect? Posted by: Michael on September 13, 2005 09:51 AM
Exactly how do the police get a semen sample from an uncooperative suspect? They have to beat it out of him? : ) Posted by: compos mentis on September 13, 2005 09:57 AM
Yall seem awfully concerned with how this semen was obtained. No worries. I got your answer. It was in the script. Posted by: rightwingsparkle on September 13, 2005 09:59 AM
Can they order a cute nurse to "assist" you? Not if you're in an HMO. Posted by: Dave in Texas on September 13, 2005 10:25 AM
Exactly how do the police get a semen sample from an uncooperative suspect? They have a doctor do a prostrate massage. "I'm a supporter of Barry Schect's Innocence Project" Megan's right. I'm all for the use of dna to prove guilt or innocence, but Scheck uses it to abuse the system, case in point: Kevin Cooper. Posted by: on September 13, 2005 11:34 AM
How did they get the semen sample? Hmmm... I don't know. In a pinch, a hypodermic can be stuck in... Posted by: ace on September 13, 2005 11:37 AM
Wow! Posted by: Uncle Jefe on September 13, 2005 11:43 AM
They have a doctor do a prostrate massage. Oh shit. I am sooooo sorry I asked the question. Posted by: Michael on September 13, 2005 11:44 AM
The cyclist was Tyler Hamilton, and he's as guilty as OJ is innocent. Posted by: fat kid on September 13, 2005 11:52 AM
I am shocked and awed... Posted by: Dogstar on September 13, 2005 11:53 AM
Exactly how do the police get a semen sample from an uncooperative suspect? My blender and ruffies stand ready to assist law enforcement in any way possible where an innocent person's fate is at stake! Posted by: Ted Kennedy on September 13, 2005 12:13 PM
I used this once in an argument about the earliest stages of life in a discussion about something I will not name. Nobody believed me that chimarism was even possible. Posted by: SarahW on September 13, 2005 01:40 PM
I gues that's "chiMERisam" Posted by: on September 13, 2005 01:41 PM
Hmm. I wonder what allah is going to do now? Posted by: on September 13, 2005 05:19 PM
I recall the term "electro-ejaculation" from an old TV movie about test tube babies or something, not sure if it's real or not, they seemed to not want to admit that they guy had to milk himself. Posted by: Dave Munger on September 13, 2005 07:10 PM
"Wait a second... The court can actually order you to jack off?" The 5th Amendment argument has been tried, and ... beaten. Uh, or so they tell me. Posted by: Knemon on September 13, 2005 08:09 PM
Chimerism is a lot more common than we thought....in medicine, it is a condition they can get after an organ transplant and the like.....that is why organ transplant patients have to take immunosuppressant drugs. Posted by: Helen on October 4, 2005 07:32 PM
ya right ... why are u sarcastic about this issue. as if chimeras do not exist ?? Posted by: cypher A on October 24, 2005 04:50 AM
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