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September 12, 2005
Searching For Alien Life Here On EarthSearching for right-handed amino acids: So how can we be sure that the world about us isn't seething with alien bugs? I began researching this with Charles Lineweaver at the Australian National University. We identified several ways in which multiple genesis episodes might have left traces in Earth's geological or biological record. The real prize would be the identification of a truly alien microbe right under our noses. But how would we spot such a thing amid the welter of familiar life? Handedness, or "chirality," refers to the orientation of atoms around a central carbon atom. The carbon atom has four points of joining with other atoms, and two different carbon atoms can join with the same four other atoms and yet be chemically distinct. That's because of how they're oriented around the central carbon atom-- if you use four of your fingers of your left hand to represent the chemical bonds to other atoms, taking your palm to be the central carbon atom, you can see that you can stick on four different atoms (just call them red, blue, green, yellow) such that the this hand-atom won't superimpose itself over, or be identical to, a "Carbon molecule" represented by the same atoms connect to the same fingers your right hand. That's what makes Splenda/sucralose, which is different from real sugar only in the chirality or arrangement of atoms around a central carbon atom, chemically distinct from real sugar or sucrose. The body can process one but can't do anything with the other except excrete it as metabolically useless. The study of "wrong-handed" amino acids is technically known as "Bizarro biology." Scientists postulate that a being constructed entirely of right-handed amino acids would say things like "Me so happy, me want to cry" and would say "Hello" when he leaves and "Goodbye" when he first shows up. He would also derive power from kryptonite, rather than being all pussified by it. No thank you to cutaway. Cutaway a good tipper, me hate him so much. Science Weenie Update: Dave Eaton, making trouble for me as usual, says that sucralose isn't different from sucrose only in its handedness. It also has a few oxygen atoms replaced by chlorine. Me love corrections. When me get corrections, me so thankful me want to pound stupid-pointy-head into a soupy pulp. posted by Ace at 12:59 PM
CommentsHere's the link. Posted by: Malibu Stacy on September 12, 2005 01:11 PM
I hate to be a science-weenie, but sucralose/splenda is not just sugar of opposite chirality, it has several oxygen atoms replaced by chlorine. http://www.elmhurst.edu/~chm/vchembook/549sucralose.html Posted by: Dave Eaton on September 12, 2005 01:13 PM
Super. My head just fucking exploded. Posted by: Hoodlumman on September 12, 2005 01:13 PM
Whoa, that's deep, Ace. Are you on dope again? As for a world of wrong-handed biologicals, I can only think of a world where cats and dogs live together. Mass hysteria, in other words. You're freakin' me out, man. Cheers, Posted by: Dave at Garfield Ridge on September 12, 2005 01:13 PM
The truth is, I like being a science weenie. I can't figure out why I hyphenated 'science weenie' earlier though. Posted by: Dave Eaton on September 12, 2005 01:16 PM
Through the looking glass, anyone? On this planet, my mother-in-law would LIKE me? Posted by: Lokki on September 12, 2005 01:18 PM
What is this happy horsecrap? We visit for the funny, not science lectures. Posted by: Slublog on September 12, 2005 01:20 PM
I leavened it with retard-friendly Bizarro analogies. Posted by: ace on September 12, 2005 01:20 PM
This is cool and all, but generally I only like to have a science post interrupt my retard-drooling if it involves robots, flying cars, or monkeys in human clothing. And frankly, I'm not even sure monkeys in human clothing can enerally qualify as "science," per se. Posted by: Rocketeer on September 12, 2005 01:29 PM
Rocketeer-- would monkeys in lab coats count? Posted by: Dave at Garfield Ridge on September 12, 2005 01:31 PM
Roger Zelazny was ahead of the curve. He had a novel in the 70's, 'Doorways in the Sand', that featured an alien machine that could reverse the handedness of objects as a plot device. That was my first encounter with the concept. Those sugar substitutes were supposed to be great and completely indiscernable from the real thing but instead they taste funny and are carcinogenic in ridiculous consumption qualities. I recently tried Minute Maid's line of 'half the sugar' fruit juices. Ugh. Rather than just cutting the sugar they try to make up for it with Splenda and it's awful. So much for cutting calories there. Simpler just to add water. Posted by: epobirs on September 12, 2005 01:38 PM
Not nice, Dave. You get me all excited about monkey-scientists, and what do I find when I click the link? A freakin' cartoon from Ace's collection of of Highlights magazine back issues. Posted by: Rocketeer on September 12, 2005 01:39 PM
I'm telling ya', Ace already linked a picture of an alien lifeform. I'd bet real money Personality Quiz Guy is an alien being. He is Yarnek of Excalbia in a shitty, rubber mask. Posted by: rdbrewer on September 12, 2005 01:39 PM
So am I to believe that Vietnamese hookers are really alien beings. Posted by: Dman on September 12, 2005 01:43 PM
Someone needs to send them a copy of Little Big Man. I think it was Shadow That Comes In Sight that was the contrary, he fits the description. Posted by: bullwinkle on September 12, 2005 01:48 PM
Those sugar substitutes were supposed to be great and completely indiscernable from the real thing but instead they taste funny and are carcinogenic in ridiculous consumption qualities. You sure it's Splenda? I can't tell the difference between splenda and sugar, and I can tell the difference between sugar and asparatame and saccharine. I hadn't heard about it being carcinogenic. I wonder if you're confusing sucralose with saccarine. Posted by: ace on September 12, 2005 01:55 PM
I think sucralose is indeed carcinogenic when you inject 55 gallons up your ass daily. Rats that acquired cancer had the equivalent. Posted by: rdbrewer on September 12, 2005 02:06 PM
Ace- You can find chiropractors and healthfood hawkers who collect Splenda "horror stories" but the open literature doesn't support any adverse health claims. Posted by: Dave Eaton on September 12, 2005 02:11 PM
Though I admit I missed the paper about injecting 55 gallons of the stuff up one's ass ;) Wonder what you'd have to pay test subjects for that one? Posted by: Dave Eaton on September 12, 2005 02:27 PM
All that, and I'd get paid too? Posted by: Sully on September 12, 2005 02:38 PM
I think sucralose is indeed carcinogenic when you inject 55 gallons up your ass daily. I've been feeling funny lately...if those 55gal sucralose enemas are giving me cancer I'm going to sue the shit out of someone and grab for that CrazyLawsuitMoney™ brass ring. Posted by: Tony on September 12, 2005 02:39 PM
I've always thought of Paul Davies as something of a loon, but I've never read his books - just reviews of his books. But if he holds the keys to the gates of Bizarro World, that's good enough for me. Posted by: geoff on September 12, 2005 02:41 PM
As a world-renowned fat guy, I can assure you, Splenda doesn't taste like sugar. It also doesn't taste like high fructose corn syrup, either. It's the Devil's work. Posted by: Dave at Garfield Ridge on September 12, 2005 02:47 PM
I'm thinking this 'handedness' thing could only be attributable to intelligent design. Kind of like the Supreme Being taping your left hand to your thigh so you'll learn to use your right hand like normal people? But every once in a while, when the Supreme Being isn't looking, you drop a tab of amino acid and pretty soon you can't remember which hand is taped to your leg. Or that you even have hands. See what I mean? Posted by: BrewFan on September 12, 2005 03:34 PM
Ah, that must be it. I'm unrepentedly left handed, so I can see through the sinister illusion of Splenda. Seriously, all the products I've tried with taste funky. Not repugnantly unpleasant but it doesn't live up to the claims. I'd rather have weak flavor than odd flavor. Posted by: epobirs on September 12, 2005 04:05 PM
epobirs- Some diet drinks mix acesulfame K with sucralose. This is known to have a bitter aftertaste, but the properties of sugar are hard to mimic with a single compound. And the job isn't just to be sweet. There are a bunch of other flavor profile aspects that the mixtures are trying to match. It's a lot more complex than I ever imagined. I think the sucralose-containing drinks I have tried tasted pretty rancid, too. But I bought some of the small packs to put in coffee and tea, and while the taste is not quite right, it isn't bad. Not like aspartame or saccharin. Posted by: Dave Eaton on September 12, 2005 04:34 PM
Ace : I hereby serve notice on you for my brain fracture lawsuit. One third of the way through reading this post my brain froze and then fractured. I calculate the damages as follows: $1.50 for replacement brain, $250,000 for medical procedures and $259,000,000,000 for pain, humilation, lawyers fees and punitive damages. Please make check out to my law firm Hookem, Screwem, and Fleecem P.O. box 896 Pendleton, Oregon. Posted by: john on September 12, 2005 08:21 PM
As far as the carcinogenic properties of the sweeteners go, aspartame was only carcinogenic to the female lab rats. It turns out the male lab rats lacked a certain gene on their DNA which the aspartame reacted to, causing the cancer. Humans lack this gene as well, so there's no problem for us. In regards to the "Bizarro" amino acid world, as far as I'm aware, there's no real way of telling at this point whether such a thing is possible. Chirality can affect the chemistry of compounds in biological systems in ways that can often be deadly. It's why the FDA requires pure enantiomers (left or right handed compounds) for drugs. The difference between left and right handed compounds can mean the difference between a mild sedative and a lethal poison. Posted by: Hal on September 12, 2005 11:51 PM
It turns out the male lab rats lacked a certain gene on their DNA which the aspartame reacted to, causing the cancer OMG - the uber-feminists are going to flip over this "genetic injustice". Posted by: Tony on September 13, 2005 12:15 AM
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