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May 22, 2020

Could You Have Picked Up a Resistance to Covid... Without Having Ever Been Infected with Covid?

A new paper suggests that 40-60% of the population already has T-cells which are activated to defend against covid, even though they've never actually encountered covid-19, because covid-19 is so similar to other coronaviruses.

To explain this on a fairly technical level which might lose some readers:

T-cells identify viruses by the little doodads sticking out of their bulbous bits, and I think the ideas is that these other coronaviruses have doodads which are not exactly like covid's but which are close enough to covid's that T-cells know to treat it as enemy (and block those doodads so they can't jimmy their way into healthy cells).

But you know, I'm speculating in a hopeful direction rather than in an apocalyptic, we-must-weld-ourselves-inside-apartments-or-we'll-all-die direction, therefore my speculation should be banned on Twitter, Facebook, and YouTube, and will not be treated as Real Science by the Fake Twitter Scientists' Club.

"... CD4+ T cell responses were detected in 40-60% of unexposed individuals. This may be reflective of some degree of crossreactive, preexisting immunity to SARSCoV-2 in some, but not all, individuals..."
— david friedberg (@friedberg) May 21, 2020

"...but it is tempting to speculate that the crossreactive CD4+ T cells may be of value in protective immunity, based on SARS mouse models "
— david friedberg (@friedberg) May 21, 2020

posted by Ace at 12:16 PM

| Access Comments


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To explain this on a fairly technical level which might lose some readers: T-cells identify viruses by the little doodads sticking out of their bulbous bits, and I think the ideas is that these other coronaviruses have doodads which are not exactly like covid's but which are close enough to covid's that T-cells know to treat it as enemy (and block those doodads so they can't jimmy their way into healthy cells). But you know, I'm speculating in a hopeful direction rather than in an apocalyptic, we-must-weld-ourselves-inside-apartments-or-we'll-all-die direction, therefore my speculation should be banned on Twitter, Facebook, and YouTube, and will not be treated as Real Science by the Fake Twitter Scientists' Club. "... CD4+ T cell responses were detected in 40-60% of unexposed individuals. This may be reflective of some degree of crossreactive, preexisting immunity to SARSCoV-2 in some, but not all, individuals..." — david friedberg (@friedberg) May 21, 2020 "...but it is tempting to speculate that the crossreactive CD4+ T cells may be of value in protective immunity, based on SARS mouse models " — david friedberg (@friedberg) May 21, 2020 posted by Ace at 12:16 PM \| Access Comments <script language="javascript" src="http://adserver.adtechus.com/addyn/3.0/5235/1131537/0/170/ADTECH;loc=700;cookie=info;target=_blank;key=key1+key2+key3+key4;grp=[group]"></script><noscript><a href="http://adserver.adtechus.com/adlink/3.0/5235/1131537/0/170/ADTECH;loc=300;key=key1+key2+key3+key4;grp=[group]" target="_blank"><img src="http://adserver.adtechus.com/adserv/3.0/5235/1131537/0/170/ADTECH;loc=300;key=key1+key2+key3+key4;grp=[group]" border="0" width="300" height="250"></a></noscript>	Recent Comments JackStraw: ">>Yeah, right AfD wants safety and security for it ..." grammie winger - cheesehead: "He wasn't a Muslim, then? 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