So, the Big, Hideous New Story That Computer Problems Have So Far Allowed Me to Avoid Commenting On | Main | Dating: Life Advice For Morons By Morons [Warden]
October 13, 2016

Nobel Prize in Medicine in 2016 Goes to Japanese Researcher into Autophagy

It's not Medial Monitoring day, but I thought I'd mention this. There are claims -- I don't know if these claims are true -- that Intermittent Fasting promotes autophagy, the cells' self-eating of their own defective parts, because the body diverts metabolic energy to self-eating when it's not digesting food from outside the body.

Anyway, here's a translation of this article.

Nobel Prize in Medicine, 2016: What is autophagy?

The Nobel Prize in Medicine in 2016 has been awarded, on October 3rd, to the Japanese biologist Yosinori Oshumi, 71, for having shed light on the mechanisms of autophagy, a process of breaking down and destroying the defective components of the cell.

This process is essential for the survival of the cells. Some mutations in the genes that control autophagy can cause disease, stated the message of the [Nobel Prize] jury, and problems in this process have, importantly, been linked to infections, to neurodegenerative diseases (when misformed proteins are not eliminated), to diabetes type 2 and to cancer.

I think I've mentioned this, but if I haven't, Taubes talks a lot about these misformed proteins, glycoproteins if I remember right, which form when a protein divides imcorrectly and then sticks to a glucose molecule. These glycoproteins collect in the brain and may be directly linked to one of the forms of Alzheimer's.

I think the problem is that other proteins are supposed to break down proteins in the brain, but there aren't any proteins that bond to this weird mutant hybrid protein-sugar molecule, so they're left to accumulate. And they cause loss of brain function in accumulation.

Supposedly a low-carb diet helps prevent this. Maybe. It's complicated; the more insulin you have in your body, apparently the less brain-clearing hormone you have. (This is all sketchy, from memory.)

And I suppose, though now I'm just speculating, that IF may promote the autophagy which removes these defective malformed proteins from the brain. (I'm just guessing on that -- because I don't think there's anything that can clear out these mutant proteins once they're formed and stuck between your neurons. But maybe autophagy eats up the badly-formed proteins which will wind up forming glycoproteins, before they can bond with sugar.)

"The discoveries of Oshumi have led to a new paradigm in the understanding of the manner in which the cell recycles its own parts." The concept of autophagy appeared in the 1960s when scientists observed for the first time the destruction by the cells of their own defective parts. The waste products of the cells is concentrated in the small vesicles, which are transported to the lysosomes, the cell organelles which destroy them [the waste products].

The understanding of this phenomenon, however, remained limited until the work of Mr. Oshumi who, in the beginning of the 1990s, led some "brilliant experiments," according to the Nobel jurists. He had virst worked on the [levures -- a scientific word I don't know], in which he had demonstrated the mechanisms of autophagy and proven them. Then, by several experiments, always among the [levures], he had proven the 15 key genes involved in this process. These results were published in 1992. He had shown that the comparable mechanisms are at work in human cells.

The biologist, professor at the Institute of Technology in Tokyo, had also notably received the Canada Garidner International Award of 2015 for his work. He is the sixth Japanese to win the Nobel Prize in Medicine.

Oh, so I looked up levure. Um, the "lev" is a root seen in the word "elevation."

It's not a scientific word -- it just means "yeast." Levure -- something that rises or raises. Makes sense.

So he did his research in yeast cells, then proved that the same mechanisms were observable in human cells.

digg this
posted by Ace at 06:48 PM

| Access Comments

Recent Comments
Anon a mouse: "Do you have any idea why that would only be the ca ..."

Margarita DeVille: "490---And they forgot how to make them also, I thi ..."

Polliwog the 'Ette: "Posted by: PJ at February 16, 2019 02:48 PM (qlTN9 ..."

OldDominionMom: " 60 JTB, it sounds like you and I could share shoe ..."

Pat*: "Not much to say about Idaho's Treasure Valley agai ..."

PJ: "I met an attorney for the railroad a few years ago ..."

hogmartin: "[i]They have 3 differentials in them (front, rear, ..."

lowandslow: ""But in all seriousness, why are wiper blades so ^ ..."

navybrat, sometime commentater: "Wifey has a Honda civic and I will be damned if I ..."

Biergood: "Have a quick question about moles. Just recently s ..."

Art Rondolet of Malmsey: "If you buy a really solid car, the high mileage ma ..."

Anon a mouse: "For whatever reason" It's the awd clutch pack. ..."

Recent Entries

Polls! Polls! Polls!
Frequently Asked Questions
The (Almost) Complete Paul Anka Integrity Kick
Top Top Tens
Greatest Hitjobs

The Ace of Spades HQ Sex-for-Money Skankathon
A D&D Guide to the Democratic Candidates
Margaret Cho: Just Not Funny
More Margaret Cho Abuse
Margaret Cho: Still Not Funny
Iraqi Prisoner Claims He Was Raped... By Woman
Wonkette Announces "Morning Zoo" Format
John Kerry's "Plan" Causes Surrender of Moqtada al-Sadr's Militia
World Muslim Leaders Apologize for Nick Berg's Beheading
Michael Moore Goes on Lunchtime Manhattan Death-Spree
Milestone: Oliver Willis Posts 400th "Fake News Article" Referencing Britney Spears
Liberal Economists Rue a "New Decade of Greed"
Artificial Insouciance: Maureen Dowd's Word Processor Revolts Against Her Numbing Imbecility
Intelligence Officials Eye Blogs for Tips
They Done Found Us Out, Cletus: Intrepid Internet Detective Figures Out Our Master Plan
Shock: Josh Marshall Almost Mentions Sarin Discovery in Iraq
Leather-Clad Biker Freaks Terrorize Australian Town
When Clinton Was President, Torture Was Cool
What Wonkette Means When She Explains What Tina Brown Means
Wonkette's Stand-Up Act
Wankette HQ Gay-Rumors Du Jour
Here's What's Bugging Me: Goose and Slider
My Own Micah Wright Style Confession of Dishonesty
Outraged "Conservatives" React to the FMA
An On-Line Impression of Dennis Miller Having Sex with a Kodiak Bear
The Story the Rightwing Media Refuses to Report!
Our Lunch with David "Glengarry Glen Ross" Mamet
The House of Love: Paul Krugman
A Michael Moore Mystery (TM)
The Dowd-O-Matic!
Liberal Consistency and Other Myths
Kepler's Laws of Liberal Media Bias
John Kerry-- The Splunge! Candidate
"Divisive" Politics & "Attacks on Patriotism" (very long)
The Donkey ("The Raven" parody)
Powered by
Movable Type 2.64