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Although there are 50 genes associated with obesity, one, called FTO, seems especially determinative, with those carrying it 70% more likely to be overweight.
It's not really a blockbuster story, but I like how the Daily Mail chooses to illustrate the fact that a simple DNA test can tell if you carry FTO:
The guy is obviously a doctor -- check out the labcoat -- and of course he needs to check if this particular beauty-magazine model has the gene for obesity.